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. 2020 Dec 9;15(12):e0243528. doi: 10.1371/journal.pone.0243528

Table 5. Multivariable Cox proportional hazard model to identify risk factors for in-hospital mortality.

Variables Univariable Multivariable
HR 95% CI P value HR 95% CI P value
Age ≥ 65 (years) 11.507 3.431–38.597 < 0.001 4.668 1.250–17.430 0.022
Male sex 3.580 1.589–8.066 0.002 1.062 0.356–3.166 0.914
Hypertension 6.026 2.391–15.186 < 0.001 1.588 0.452–5.581 0.470
Diabetes mellitus 7.100 3.103–16.249 < 0.001 2.470 0.900–6.783 0.079
Neutrophil/lymphocyte ratio 1.223 1.162–1.286 < 0.001 1.167 1.078–1.264 < 0.001
Blood urea nitrogen (mg/dL) 1.075 1.055–1.095 < 0.001 0.990 0.936–1.048 0.738
eGFR < 60 (ml/min/1.73 m2) 10.255 4.583–22.949 < 0.001 1.318 0.352–4.932 0.682
Albumin (g/dL) 0.099 0.053–0.183 < 0.001 0.378 0.120–1.191 0.097
C-reactive protein (mg/dL) 1.141 1.098–1.185 < 0.001 0.898 0.793–1.016 0.089
Creatine kinase (U/L) 1.002 1.000–1.003 0.006 1.002 1.001–1.004 0.007
Lactate dehydrogenase (U/L) 1.002 1.001–1.002 < 0.001 1.001 1.000–1.003 0.104
Severe acute kidney injury 38.355 16.964–86.721 < 0.001 12.199 4.235–35.141 < 0.001