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. Author manuscript; available in PMC: 2021 Aug 10.
Published in final edited form as: J Control Release. 2020 May 5;324:194–203. doi: 10.1016/j.jconrel.2020.04.052

Figure 2. Optimization of the DNA-loaded SMOF NP formulation using HEK 293 cells.

Figure 2.

(A) Optimization of the feed weight ratio of the payload over the SMOF reactants, feed weight ratio of the silica reactants to the MOF reactant, and the emulsification method. (B) Optimization of the molar ratio of the three silica reactants TEOS/APTES/TESPIC. The optimal SMOF NP formulation is highlighted by a black bar. NS: not significant; *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001; n = 3.