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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Ultrasound Med Biol. 2020 Jun 16;46(9):2276–2286. doi: 10.1016/j.ultrasmedbio.2020.05.010

Figure 1:

Figure 1:

Image processing and analysis pipeline for prediction of transarterial chemotherapy (TACE) response for an individual patient with hepatocellular carcinoma (HCC). The contrast-enhanced ultrasound (CEUS) image sequence was aligned using the first frame as reference. Tissue signal was removed, and vasculature was enhanced at multiple scales before segmentation. Using morphological operations, tumor microvascular features were extracted. A distance-weighted discriminator was trained using the CEUS image-derived morphological features and leave-one-out validation.