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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: J Leukoc Biol. 2020 Aug 17;108(4):1037–1050. doi: 10.1002/jlb.1hi0620-230r

FIGURE 3. Osteoclastogenic potential of CD11b+c-fms+Ly6Chi population in BM and SPL is enhanced following Pg infection.

FIGURE 3

(A) TRAP+ MNC in the cultures of BM CD11b+ c-fms+Ly6C− and CD11b+c-fms+Ly6Chi populations in Ctrl and Pg-infected mice (n=6). (B) F-actin ring formation in the cultures of BM CD11b+c-fms+Ly6Chi populations of Ctrl and Pg-infected mice (n=6). (C) Bone resorption area by WGA staining in the cultures of BM CD11b+c-fms+Ly6Chi in Ctrl and Pg-infected mice (n=4). (D) TRAP+ MNC in the cultures of SPL CD11b+c-fms+Ly6C− and CD11b+c-fms+Ly6Chi populations of Ctrl and Pg-infected mice (n=6). (E) F-actin ring formation in the cultures of SPL CD11b+c-fms+Ly6Chi of Ctrl and Pg-infected mice (n=6). (F) Bone resorption area by WGA staining in the cultures of SPL CD11b+c-fms+Ly6Chi of Ctrl and Pg-infected mice (n=4). Data are expressed as mean ± SD. Scale bar, 100 μm. *P < 0.05, **P < 0.01, ***P < 0.001.