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. Author manuscript; available in PMC: 2020 Dec 9.
Published in final edited form as: Nanomedicine. 2017 Apr 13;13(6):1863–1867. doi: 10.1016/j.nano.2017.04.003

Figure 1. Reference NP corrects for heterogeneity within and between samples.

Figure 1.

(A) Representative images of Dil (red) and DiO (green) NPs demonstrating co-localization (overlay). (B) Independent regions within one sample showing varying intensity of Dil (top) and corresponding DiO-NP (bottom) images. Quantification of mean intensity for: (C) single sample of Dil-NP at 50 pg/mL or (D) 5 simultaneously collected samples from a single mouse before (black circles) and after referencing (gray squares); lines connect identical images. Values are normalized to the mean of their respective group (referenced or unreferenced). Scale bars represent 100 μm.