Table 2.
Hazard ratios for the incidence of T2DM according to the four phenotype groups and quartile of LAP.
| N | T2DM cases | Incidence density | Unadjusted model | Multivariable adjusted model# | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P values | HR (95% CI) | P values | ||||
| HTGW phenotype | |||||||
| Total | |||||||
| NTNW | 8,615 | 211 | 3.347 | 1.000 (ref) | — | 1.000 (ref) | — |
| NTGW | 3,454 | 269 | 10.812 | 3.331 (2.781-3.989) | <0.001 | 3.422 (2.833-4.135) | <0.001 |
| HTNW | 1,593 | 96 | 8.192 | 2.493 (1.959-3.174) | <0.001 | 2.542 (1.994-3.240) | <0.001 |
| HTGW | 2,055 | 291 | 19.958 | 6.301 (5.277-7.523) | <0.001 | 6.249 (5.199-7.511) | <0.001 |
| Men | |||||||
| NTNW | 4,322 | 116 | 3.700 | 1.000 (ref) | — | 1.000 (ref) | — |
| NTGW | 683 | 71 | 14.462 | 4.015 (2.988-5.394) | <0.001 | 4.071 (3.014-5.499) | <0.001 |
| HTNW | 942 | 52 | 7.496 | 2.037 (1.469-2.825) | <0.001 | 2.205 (1.584-3.070) | <0.001 |
| HTGW | 626 | 91 | 20.604 | 5.733 (4.357-7.544) | <0.001 | 5.976 (4.493-7.946) | <0.001 |
| Women | |||||||
| NTNW | 4,293 | 95 | 2.997 | 1.000 (ref) | — | 1.000 (ref) | — |
| NTGW | 2,771 | 198 | 9.915 | 3.410 (2.670-4.356) | <0.001 | 3.214 (2.504-4.126) | <0.001 |
| HTNW | 651 | 44 | 9.202 | 3.171 (2.218-4.533) | <0.001 | 3.049 (2.127-4.370) | <0.001 |
| HTGW | 1,429 | 200 | 19.677 | 6.978 (5.466-8.909) | <0.001 | 6.299 (4.892-8.111) | <0.001 |
| Quartile of LAP ∗ | |||||||
| Total | |||||||
| Q1 (LAP < 9.9) | 3,823 | 76 | 2.731 | 1.000 (ref) | — | 1.000 (ref) | — |
| Q2 (LAP 9.9-20.1) | 3,848 | 87 | 3.082 | 1.153 (0.848-1.569) | 0.364 | 1.169 (0.857-1.595) | 0.325 |
| Q3 (LAP 20.2-38.4) | 3,839 | 224 | 7.984 | 2.972 (2.291-3.856) | <0.001 | 2.903 (2.226-3.784) | <0.001 |
| Q4 (LAP ≥ 38.5) | 3,837 | 465 | 16.949 | 6.523 (5.118-8.314) | <0.001 | 6.298 (4.911-8.077) | <0.001 |
| Men | |||||||
| Q1 (LAP < 7.7) | 1,582 | 39 | 3.425 | 1.000 (ref) | — | 1.000 (ref) | — |
| Q2 (LAP 7.7-16.6) | 1,581 | 41 | 3.593 | 1.075 (0.693-1.666) | 0.747 | 1.123 (0.719-1.752) | 0.610 |
| Q3 (LAP 16.7-34.7) | 1,580 | 69 | 5.928 | 1.743 (1.177-2.582) | 0.006 | 1.839 (1.230-2.748) | 0.003 |
| Q4 (LAP ≥ 34.8) | 1,583 | 172 | 15.096 | 4.535 (3.203-6.421) | <0.001 | 4.773 (3.324-6.854) | <0.001 |
| Women | |||||||
| Q1 (LAP < 11.8) | 2,255 | 35 | 2.100 | 1.000 (ref) | — | 1.000 (ref) | — |
| Q2 (LAP 11.8-22.3) | 2,255 | 59 | 3.550 | 1.718 (1.131-2.610) | 0.011 | 1.633 (1.073-2.485) | 0.022 |
| Q3 (LAP 22.4-40.8) | 2,254 | 150 | 9.164 | 4.480 (3.101-6.474) | <0.001 | 4.150 (2.865-6.013) | <0.001 |
| Q4 (LAP ≥ 40.9) | 2,257 | 287 | 17.882 | 9.058 (6.377-12.867) | <0.001 | 8.063 (5.645-11.516) | <0.001 |
Incidence density, per 1000 person-years; NTNW: normal TG level and normal waist; NTGW: normal TG level and central obesity; HTNW: increased TG level and normal WC; HTGW: increased TG level and central obesity. #Adjusted for age, smoking status, drinking status, physical activity, family history of T2DM, family income, and education; adjusted for sex in the total population at the same time. ∗370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.