Table 3.
Hazard ratios for the incidence of T2DM in different metabolic groups.
| N | T2DM cases | Incidence density | Unadjusted model | Multivariable adjusted model# | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P values | HR (95% CI) | P values | ||||
| High LAP∗ | |||||||
| No | 9,695 | 255 | 3.593 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 5,652 | 597 | 14.710 | 4.243 (3.660-4.913) | <0.001 | 4.094 (3.530-4.755) | <0.001 |
| HTGW | |||||||
| No | 13,662 | 576 | 5.781 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 2,055 | 291 | 19.958 | 3.611 (3.136-4.158) | <0.001 | 3.387 (2.929-3.916) | <0.001 |
| Central obesity | |||||||
| No | 10,208 | 307 | 4.106 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 5,509 | 560 | 14.192 | 3.585 (3.119-4.121) | <0.001 | 3.671 (3.163-4.260) | <0.001 |
| Increased BP | |||||||
| No | 8,705 | 311 | 4.858 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 7,012 | 556 | 11.075 | 2.281 (1.986-2.621) | <0.001 | 2.111 (1.820-2.448) | <0.001 |
| Increased FPG | |||||||
| No | 12,943 | 403 | 4.259 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 2,774 | 464 | 23.668 | 5.747 (5.028-6.567) | <0.001 | 5.532 (4.829-6.337) | <0.001 |
| Increased TG | |||||||
| No | 12,069 | 480 | 5.459 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 3,648 | 387 | 14.715 | 2.777 (2.429-3.175) | <0.001 | 2.719 (2.375-3.114) | <0.001 |
| Reduced HDL-C | |||||||
| No | 12,396 | 640 | 7.144 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | 3,321 | 227 | 9.212 | 1.194 (1.026-1.390) | 0.022 | 1.209 (1.034-1.413) | 0.017 |
| MS | |||||||
| No | 13,120 | 473 | 4.937 | 1.000 (ref) (ref) | — | 1.000 (ref) (ref) | — |
| Yes | 2,597 | 394 | 21.402 | 4.419 (3.866-5.052) | <0.001 | 4.224 (3.671-4.860) | <0.001 |
| Number of MS components | |||||||
| 0 | 4,250 | 54 | 1.726 | 1.000 (ref) | — | 1.000 (ref) | — |
| 1 | 4,909 | 125 | 3.496 | 2.014 (1.463-2.771) | <0.001 | 1.996 (1.441-2.763) | <0.001 |
| 2 | 3,508 | 248 | 9.754 | 5.704 (4.249-7.656) | <0.001 | 5.728 (4.238-7.741) | <0.001 |
| 3 | 2,032 | 239 | 16.381 | 9.589 (7.137-12.884) | <0.001 | 9.437 (6.962-12.793) | <0.001 |
| 4 | 847 | 149 | 24.809 | 14.423 (10.564-19.691) | <0.001 | 14.846 (10.774-20.458) | <0.001 |
| 5 | 171 | 52 | 44.734 | 26.219 (17.914-38.372) | <0.001 | 24.652 (16.612-36.583) | <0.001 |
Incidence density, per 1000 person-years; BP: blood pressure; FPG: fast plasma glucose; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome. #Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education. ∗Grouped by optimal cutoff value (LAP = 27.90) calculating through ROC curve analysis, 370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.