Table 4.
Interactions between HTGW and other components of metabolic syndrome on the risk of T2DM.
| HTGW | MS components | N | T2DMcases | Incidence density | Unadjusted model | Multivariable adjusted model# | ||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||||
| HTGW | Increased BP | |||||||
| No | No | 8,038 | 234 | 3.953 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 667 | 77 | 15.956 | 4.180 (3.231-5.407) | <0.001 | 4.013 (3.091-5.210) | <0.001 |
| No | Yes | 5,624 | 342 | 8.455 | 2.124 (1.799-2.508) | <0.001 | 1.970 (1.653-2.348) | <0.001 |
| Yes | Yes | 1,388 | 214 | 21.937 | 5.808 (4.825-6.991) | <0.001 | 5.251 (4.329-6.369) | <0.001 |
| SI (95% CI): 1.117 (0.846-1.475) | SI (95% CI): 1.067 (0.799-1.425) | |||||||
| AP (95% CI): 0.087 (-0.12-0.294) | AP (95% CI): 0.051 (-0.169-0.271) | |||||||
| REEI (95% CI): 0.504 (-0.734-1.742) | REEI (95% CI): 0.268 (-0.907-1.442) | |||||||
| HTGW | Increased FPG | |||||||
| No | No | 11,581 | 296 | 3.494 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 1,362 | 107 | 10.815 | 3.200 (2.565-3.992) | <0.001 | 3.017 (2.409-3.778) | <0.001 |
| No | Yes | 2,081 | 280 | 18.770 | 5.500 (4.671-6.476) | <0.001 | 5.286 (4.478-6.238) | <0.001 |
| Yes | Yes | 693 | 184 | 39.258 | 12.202 (10.15-14.669) | <0.001 | 11.573 (9.588-13.971) | <0.001 |
| SI (95% CI): 1.672 (1.36-2.056) | SI (95% CI): 1.678 (1.358-2.072) | |||||||
| AP (95% CI): 0.369 (0.252-0.486) | AP (95% CI): 0.369 (0.251-0.488) | |||||||
| REEI (95% CI): 4.502 (2.489-6.516) | REEI (95% CI): 4.271 (2.33-6.212) | |||||||
| HTGW | Reduced HDL-C | |||||||
| No | No | 11,031 | 451 | 5.632 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 1,365 | 189 | 19.886 | 3.858 (3.255-4.573) | <0.001 | 3.697 (3.108-4.397) | <0.001 |
| No | Yes | 2,631 | 125 | 6.389 | 1.058 (0.868-1.290) | 0.575 | 1.117 (0.913-1.366) | 0.284 |
| Yes | Yes | 690 | 102 | 20.092 | 3.331 (2.686-4.130) | <0.001 | 3.140 (2.514-3.923) | <0.001 |
| SI (95% CI): 0.799 (0.567-1.126) | SI (95% CI): 0.761 (0.534-1.084) | |||||||
| AP (95% CI): -0.176 (-0.465-0.113) | AP (95% CI): -0.214 (-0.516-0.088) | |||||||
| REEI (95% CI): -0.586 (-1.468-0.296) | REEI (95% CI): -0.673 (-1.528-0.182) | |||||||
Incidence density, per 1000 person-years; HTGW: increased TG level and central obesity; BP: blood pressure; FPG: fast plasma glucose; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome; SI: synergy index; AP: attributable proportion due to the interaction; RERI: relative excess risk due to the interaction. #Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education.