Table 5.
Interactions between high LAP and other components of metabolic syndrome on the risk of T2DM.
| High LAP∗ | MS components | N | T2DM cases | Incidence density | Unadjusted model | Multivariable adjusted model# | ||
|---|---|---|---|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |||||
| High LAP | Increased BP | |||||||
| No | No | 6,210 | 123 | 2.684 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 2,251 | 180 | 10.961 | 4.195 (3.335-5.276) | <0.001 | 4.169 (3.306-5.257) | <0.001 |
| No | Yes | 3,485 | 132 | 5.252 | 1.931 (1.510-2.468) | <0.001 | 1.799 (1.395-2.320) | <0.001 |
| Yes | Yes | 3,401 | 417 | 17.259 | 6.651 (5.440-8.133) | <0.001 | 6.15 (4.987-7.584) | <0.001 |
| SI (95% CI): 1.370 (1.110-1.690) | SI (95% CI): 1.298 (1.045-1.611) | |||||||
| AP (95% CI): 0.229 (0.099-0.360) | AP (95% CI): 0.192 (0.052-0.332) | |||||||
| REEI (95% CI): 1.526 (0.577-2.475) | REEI (95% CI): 1.182 (0.259-2.105) | |||||||
| High LAP | Increased FPG | |||||||
| No | No | 8,497 | 134 | 2.152 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 4,105 | 257 | 8.601 | 4.088 (3.318-5.038) | <0.001 | 4.015 (3.25-4.96) | <0.001 |
| No | Yes | 1,198 | 121 | 13.911 | 6.464 (5.055-8.265) | <0.001 | 6.33 (4.936-8.118) | <0.001 |
| Yes | Yes | 1,547 | 340 | 31.760 | 15.911 (13.026-19.434) | <0.001 | 15.198 (12.393-18.638) | <0.001 |
| SI (95% CI): 1.744 (1.445-2.104) | SI (95% CI): 1.701 (1.406-2.059) | |||||||
| AP (95% CI): 0.400 (0.298-0.502) | AP (95% CI): 0.385 (0.279-0.491) | |||||||
| REEI (95% CI): 6.359 (4.063-8.655) | REEI (95% CI): 5.853 (3.620-8.086) | |||||||
| High LAP | Reduced HDL-C | |||||||
| No | No | 8,101 | 215 | 3.640 | 1.000 (ref) | — | 1.000 (ref) | — |
| Yes | No | 3,961 | 412 | 14.654 | 4.303 (3.649-5.075) | <0.001 | 4.203 (3.554-4.970) | 0.706 |
| No | Yes | 1,594 | 40 | 3.360 | 0.869 (0.620-1.218) | 0.415 | 0.937 (0.666-1.316) | <0.001 |
| Yes | Yes | 1,691 | 185 | 14.837 | 3.832 (3.147-4.665) | <0.001 | 3.735 (3.051-4.573) | <0.001 |
| SI (95% CI): 0.893 (0.693-1.150) | SI (95% CI): 0.871 (0.672-1.129) | |||||||
| AP (95% CI): -0.089 (-0.296-0.118) | AP (95% CI): -0.108 (-0.322-0.106) | |||||||
| REEI (95% CI): -0.341 (-1.105-0.424) | REEI (95% CI): -0.404 (-1.171-0.363) | |||||||
Incidence density, per 1000 person-years; HTGW: increased TG level and central obesity; BP: blood pressure; FPG: fast plasma glucose; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome; SI: synergy index; AP: attributable proportion due to the interaction; RERI: relative excess risk due to the interaction. #Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education. ∗Grouped by optimal cutoff value (LAP = 27.90) calculating through ROC curve analysis, 370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.