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. 2020 Nov 30;147(22):dev190173. doi: 10.1242/dev.190173

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© 2020. Published by The Company of Biologists Ltd

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Fig. 3. — ZFP423 is expressed in ectodermal and mesodermal derivatives of the developing hChP. (A-C) Embryos from a Zfp423 β-galactosidase gene trap line (see text) were analyzed by LacZ staining, showing that Zfp423 starts to be expressed at E7.5 in the neuroectoderm, and at E8.5 and E9.5 is strongly expressed in the hindbrain. (D,E) Immunostaining of parasagittal cerebellar sections. At E10.5 (D), Zfp423 is present in the progenitors of the hChP epithelium (arrowheads) adjacent to the IV ventricle. At E12.5 (E), Zfp423 is expressed exclusively in the proliferating epithelial cells labeled by EdU (arrows), whereas it is completely absent in the mitotically quiescent cells (arrowheads). PHb, presumptive hindbrain; Hb, hindbrain; Mid, midbrain; Sc, spinal cord; S, somites; IV, fourth ventricle; Url, upper rhombic lip; Lrl, lower rhombic lip. Scale bar: 75 μm in A; 125 μm in B; 175 μm in C; 50 μm in D,E.