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. 2020 Jul 14;59(22):2871–2877. doi: 10.2169/internalmedicine.5278-20

Table.

Characteristics of the Present and Previously Reported Patients with CCS Associated with MN.

References Age/Sex Onset of MN at the diagnosis of CCS Treatments for CCS Additional treatments for MN Patient outcome
10 41/M 5 years before Low anterior resection due to rectal adenocarcinoma None Remission
11 64/M 10 months after Right hemicolectomy due to ascending colon mucinous adenocarcinoma and oral PSL (40 mg/day, tapered later) Reintroduction of PSL Remission
12 17/M A few months after CyA CyA Remission
13 59/M 30 years before Total gastrectomy due to gastric tubular adenocarcinoma None ND
14 71/M 12 months after PSL and azathioprine (75 mg/day) CyA and rituximab in addition to azathioprine Remission§
The present case 47/M 29 months after PSL Pulse methylprednisolone (tapered later) and CyA Remission

Remission was defined as both regression of clinical symptoms of CCS and proteinuria. No endoscopic findings after treatment were described. §In this case, symptoms of CCS improved after additional CyA treatment, whereas his proteinuria did not resolve. Rituximab resulted in a regression of his MN and endoscopic findings. CCS: Cronkhite-Canada Syndrome, MN: membranous nephropathy, CyA: cyclosporine A, PSL: prednisolone, M: male, ND: not described