Fig. 3. LOAd703 controls tumor growth in vivo.
RPMI-8226 cells were subcutaneously injected in immunodeficient BALB/c nude mice (n = 5 per group). Palpable tumors were injected 6× with LOAd(−) or LOAd703 (1 × 109 FFU) or PBS/saline as negative control at time-points indicated by arrows in a and c. Mice were treated either intratumorally (a, b) or intravenously (c, d). Mean tumor size + SD is displayed in graphs a and c. Survival curves are shown in b and d. Statistically differences in tumor size were analyzed with Kruskal–Wallis test followed by Dunn’s multiple comparisons test. Differences in survival were calculated with Log-rank test.