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. 2020 Nov 26;11:570920. doi: 10.3389/fimmu.2020.570920

Figure 2.

Figure 2

Effects of BAFF blockade on survival, multiple organ dysfunction and systemic inflammatory response of LPS-induced septic mice. Septic mice (n=10 for each group) were intraperitoneally injected with 50ug anti-BAFF antibody or control antibody. Mice were euthanatized and blood samples were collected 4 h after LPS challenge. (A) Survival rate of septic mice in different groups. ** indicates P<0.01 compared with LPS group. (B) Levels of serological markers for organ injury, including ALT, AST, Cr and LDH. **P<0.01 compared with control group; # and ## indicates P<0.05 and P<0.01, respectively compared with LPS group. (C) Levels of inflammatory cytokines in the serum, including IL-1β, IL-6, TNF-α and IL-10. **P<0.01 compared with control group; # indicate P<0.05 compared with LPS group.