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. 2020 Nov 26;11:570920. doi: 10.3389/fimmu.2020.570920

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Copyright © 2020 Quan, Chen, Yan, Zhang, Zhao and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of BAFF blockade on intestinal inflammation and permeability. Septic mice (n=10 for each group) were intraperitoneally injected with 50ug anti-BAFF antibody or control antibody. Mice were euthanatized and samples were collected 4 h after LPS challenge. (A) The mRNA expression of inflammatory cytokines in the ileum tissues, including IL-1β, IL-6, TNF-α and IL-10. (B) The mRNA expression of inflammatory cytokines of primary intestinal epithelial cells, including IL-1β, IL-6, TNF-α and IL-10. (C) MPO concentrations in the ileum tissues of different groups. (D) The levels of FITC-dextran 4kDa and D-lactate in the serum of different groups, which reflects the intestinal permeability. **P<0.01 compared with control group; ^# and ^## indicate P<0.05 and P<0.01, respectively compared with LPS group.