Table 6.
Clinical, serum biochemistry, and cardiac ultrasound parameters in the replica population.
| Overall (n = 1,379) | sUA>5.6 mg/dl (n = 532) | sUA ≤5.6 mg/dl (n = 847) | p | Females (n = 587) | Males (n = 782) | p | |
|---|---|---|---|---|---|---|---|
| Clinical | |||||||
| Age, years | 52.9, 13.7 | 52.0, 14.6 | 53.5, 13.1 | <0.05 | 55.9, 12.4 | 50.6, 14.1 | <0.001 |
| Men, n (%) | 786 (57) | 436 (82) | 350 (42) | <0.01 | 587 (43) | 782 (57) | n.a. |
| BMI, kg/m2 | 27.5, 4.4 | 28.6, 4.1 | 26.8, 4.4 | <0.01 | 27.3, 4.9 | 27.5, 3.9 | 0.29 |
| SBP, mmHg | 143.7, 18.9 | 144.5, 18.5 | 143.2, 19.1 | 0.21 | 144.8, 19.8 | 142.2, 18.1 | 0.07 |
| DBP, mmHg | 88.9, 11.5 | 89.9, 11.6 | 88.3, 11.5 | <0.02 | 87.8, 11.5 | 89.6, 11.4 | <0.006 |
| HR, beats/min | 75.1, 27.9 | 74.2, 12.6 | 75.6, 34.2 | 0.39 | 74.9, 12.0 | 75.1, 35.2 | 0.86 |
| Serum biochemistry | |||||||
| Triglycerides, mg/dl | 122.9, 69.4 | 138.9, 74.1 | 112.7, 64.1 | <0.01 | 111.9, 58.0 | 130.9, 75.5 | <0.001 |
| TC, mg/dl | 200.1, 38.1 | 200.8, 36.7 | 199.7, 38.9 | 0.60 | 206.0, 38.2 | 195.0, 37.2 | <0.001 |
| HDL, mg/dl | 52.6, 13.7 | 48.6, 12.5 | 55.2, 13.9 | <0.01 | 59.3, 13.5 | 47.7, 11.6 | <0.001 |
| LDL, mg/dl | 122.6, 35.5 | 124.6, 33.3 | 121.3, 3, 696 | 0.12 | 125.7, 34.8 | 120.2, 35.8 | <0.034 |
| sGlucose, mg/dl | 96.7, 20.5 | 98.4, 18.5 | 95.6, 21.6 | <0.01 | 96.1, 24.3 | 97.0, 17.0 | 0.46 |
| sCreatinine, mg/dl | 0.9, 0.3 | 1.1, 0.3 | 0.9, 0.2 | <0.01 | 0.8, 0.3 | 1.0, 0.2 | <0.001 |
| sUrea, mg/dl | 37.4, 12.6 | 39.2, 13.5 | 36.3, 11.9 | <0.01 | 37.7, 14.1 | 37.2, 11.3 | 0.47 |
| sUA, mg/dl | 5.2, 1.4 | 6.6, 0.9 | 4.3, 0.8 | <0.01 | 4.4, 1.1 | 5.8, 1.3 | <0.001 |
| Cardiac ultrasound | |||||||
| LVMi, g/m2.7 | 43.6, 9.0 | 44.2, 8.5 | 43.1, 9.2 | <0.05 | 43.6, 9.4 | 43.5, 8.6 | 0.90 |
| LVEF, % | 67.5, 4.4 | 67.304.5 | 67.6, 4.4 | 0.30 | 67.8, 4.4 | 67.1, 4.4 | <0.01 |
| RWT, % | 0.38, 0.04 | 0.38, 0.04 | 0.38, 0.04 | 0.98 | 0.38, 0.04 | 0.37, 0.03 | <0.013 |
| E/A | 1.1, 0.3 | 1.1, 0.3 | 1.0, 0.3 | 0.10 | 1.0, 0.3 | 1.1, 0.3 | <0.001 |
BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; TC, total cholesterol; HDL, high-density lipoprotein; LDL, low-density lipoprotein; sGlucose, serum glucose; sCreatinine, serum creatinine; sUrea, serum urea; sUA, serum uric acid. LVMi, left ventricular mass index; LVEF, left ventricular ejection fraction; RWT, relative wall thickness; E, early-wave transmitral diastolic velocity; A, late-wave transmitral diastolic velocity; Data are presented as means ± SE unless otherwise indicated. p-values were calculated by unpaired t-test for continuous variables, or χ2 test for frequencies. Bold values indicate statistical significance (p < 0.05).