Figure 1.

Differentially expressed long non-coding RNAs (lncRNAs) detected by RNA-Seq in adult S. mansoni females treated with 5-AzaC. These results were obtained by re-analysis of the RNA-Seq data from Geyer et al.¹⁶ using the S. mansoni lncRNA transcriptome published in Maciel et al.³¹ as reference. In Geyer et al.¹⁶, parasites were cultured either in the presence or absence of 491 μM 5-AzaC for 48 h. LncRNA gene expression levels identified in this RNA-Seq dataset are shown with a volcano plot, which displays the differentially expressed lncRNAs between 5-AzaC-treated and control S. mansoni females (red dots, showing FDR < 0.05 and log2FC > 0.59 or < -0.59, dotted lines). Grey dots represent non-differentially expressed lncRNAs. 912 lncRNAs were considered significantly differentially expressed, being 522 long intergenic ncRNAs, 358 antisense lncRNAs and 32 sense lncRNAs.