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. 2020 Dec 9;10:21565. doi: 10.1038/s41598-020-78669-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Distribution of 5-AzaC-affected long non-coding RNAs and protein-coding genes among the weighted gene co-expression network (WGCNA) modules (represented by life-cycle stages and tissues). (A) Number of lncRNAs detected in each of 15 different WGCNA modules, according to Maciel et al.³¹; note that different modules are associated to the same S. mansoni life-cycle stage/tissue. (B) Number of lncRNAs upregulated in 5-AzaC treated females in each of the 15 WGCNA modules. (C) Number of lncRNAs downregulated in 5-AzaC treated females in each of the 15 WGCNA modules. (D) Number of protein-coding genes detected in each of 15 different WGCNA modules, according to Maciel et al.³¹; note that different modules are associated to the same S. mansoni life-cycle stage/tissue. (E) Number of protein-coding genes upregulated in 5-AzaC treated females in each of the 15 WGCNA modules. (F) Number of protein-coding genes downregulated in 5-AzaC treated females in each of the 15 WGCNA modules.