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. 2020 Dec 9;10:21510. doi: 10.1038/s41598-020-78488-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Ca_V3.3. KO mice display faster induction time, but have similar requirement for hypnotic and immobilizing effects of isoflurane when compared to the WT mice. (A) Time of induction at 1.2% isoflurane for the WT versus Ca_V3.3 KO mice with 15% cyclodextrin (vehicle). Mutant mice had a faster induction time in comparison to the WT mice (unpaired two-tailed t-test: t₁₇ = 2.468, *p = 0.025). (B) Percent isoflurane at LORR for the WT versus Ca_V3.3 KO mice with 15% cyclodextrin. No significant difference was identified between two cohorts (unpaired two-tailed t-test: t₁₈ = 0.557, p = 0.584). (C) Percent isoflurane at LOWR for the WT versus Ca_V3.3 KO mice with 15% cyclodextrin. There was no significant difference in % isoflurane required to reach LOWR between the WT and Ca_V3.3 KO mice (unpaired two-tailed t-test: t₁₈ = 0.447, p = 0.660).