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. 2020 Dec 9;10:21510. doi: 10.1038/s41598-020-78488-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Selective pharmacological inhibition of T-channels with TTA-P2 facilitates anesthetic induction with isoflurane in the WT and mutant mice. Both WT and Ca_V3.3 KO mice were injected with vehicle first (data from Fig. 1A) or TTA-P2 on different day and placed in a chamber set at 1.2% isoflurane after a 30-min wait period. Successful induction was determined when a mouse failed to right within a 30-s period. Note that both cohorts demonstrated a significant treatment difference (two-way RM ANOVA: F_1,17 = 127.40, p < 0.001). However, the Ca_V3.3 KO mice had overall faster induction times when compared to the WT group (two-way repeated measure (RM) ANOVA: F_1,17 = 23.87, ***p < 0.001).