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. 2020 Dec 9;10:21521. doi: 10.1038/s41598-020-76504-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cytotoxicity assay of Sorafenib (SO), FPEG-MLDH, FPVA-MLDH, FPEGSO-MLDH and FPVASO-MLDH against normal 3T3 cells at 72 h. Results were calculated as mean ± standard deviation for n = 3 independent experiments. * p < 0.05 compared to control (untreated cells) and treatment group using the ANOVA and Duncan’s Multiple Range Test.