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. 2020 Dec 9;10:21530. doi: 10.1038/s41598-020-78560-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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High TLS score associated with improved overall survival in certain tumor types. (a) Forest plot demonstrated the survival impact of TLS level for each tumor type. Tumors were categorized into high TLS scoring (> the second tertile), intermediate TLS scoring (between the first and the second tertile) and low TLS scoring (< the first tertile) for each tumor type. Hazard Ratio (5–95% confidence interval) were obtain by cox regression survival analysis. (b) Kaplan–Meier plots of overall survival difference between tumors with high TLS scoring and low TLS scoring in LIHC. (c) Kaplan–Meier plots of overall survival difference between tumors with high TLS scoring and low TLS scoring in OV. (d) Kaplan–Meier plots of overall survival difference between tumors with high TLS scoring and low TLS scoring in SKCM. (e) Kaplan–Meier plots of overall survival difference between tumors with high TLS scoring and low TLS scoring in UCEC.