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. 2020 Dec 9;11:6319. doi: 10.1038/s41467-020-20139-7

Fig. 4. Monocytes and macrophages dominate SARS-CoV-2 lung immune response.

Fig. 4

a Expression heatmap of genes involved with SARS-CoV-2 viral entry, macrophage/monocytes, and MHC Class I. b Immunohistochemical quantitation of immune cell subsets in lung samples for CD163, CD3, CD4, CD8, CD56, CD20, and CD138. Box-and-whisker plot, center line, median; box limits, upper and lower quartiles; whiskers, range. P-value two-tailed t-test. (one section per case. n = 20). c Representative images of CD163 IHC staining in virus high and virus low case 10×, scale bar = 200 μm. d Cell fraction (%) of immune cell estimated in lung tissue obtained by deconvolution of bulk RNA-seq data using CIBERSORTx. Bar = mean. P-value two-tailed t-test. high (red) and low (blue) expression of immune cells (n = 15). Source data are provided as a Source data file.