Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 9;11:6319. doi: 10.1038/s41467-020-20139-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a Differential expression of all genes between SARS-CoV-2 positive/negative regions within each tissue. Horizontal position shows genes’ log2 fold-change, with points farther right having higher expression in SARS-CoV-2 positive regions. Vertical position shows −log10(p-value), which increases with statistical significance. Red points show genes that were consistently up-regulated, blue points show genes that were consistently downregulated in SARS-CoV-2 positive regions across the 6 patient tissues. Each gene has the same point color in all 6 panels. b Genes with consistent differential expression between SARS-CoV-2 positive/negative regions across all tissues. Only consistently up/downregulated genes (red/blue in a) are shown. Grid color shows log2 fold-change, with red indicating higher expression in virus-positive regions. Results with p < 0.01 (heteroscedastic 2-sided t-test) are given color. Columns are ordered by hierarchical clustering. c Protein differential expression between SARS-CoV-2 positive/negative regions. Only proteins with FDR < 0.05 in at least one tissue are shown. Grid color shows log2 fold-change, with red indicating higher expression in virus-positive regions. Results with p < 0.01 (unpaired, heteroscedastic t-test) are given color. Columns are ordered by hierarchical clustering. d Spatially-resolved expression of viral and interferon signaling genes. Rows show distinct gene sets; columns show distinct tissues. Pie position shows the physical location of regions within each tissue. Wedge volume shows a gene’s background-subtracted expression; within each row, all genes are scaled to have the same maximum. Wedge color denotes whether a region was classified SARS-CoV-2 positive or negative by RNA-ISH. Source data are provided as a Source data file.