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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Cytokine. 2020 Oct 28;137:155334. doi: 10.1016/j.cyto.2020.155334

Figure 3. Effect of recombinant IL-38 on SCW fragment-induced arthritis.

Figure 3.

Mice were pretreated i.p. with either vehicle of recombinant human IL-38 (3–152) 24, 12 and 2 hours before intraarticular instillation of SCW fragments under the patella into the synovial compartment.A. Macroscopic scoring of exposed inflamed knee joint. Mean ±SEM, ***p < 0.001, n=10 mice.B. cell influx scoring on histological sections from mice shown in A by two blinded investigators. Mean ±SEM, ***p < 0.001.C-D. Representative hematoxylin-eosin stained sections of whole knee joints of vehicle (C) and IL-38 treated mice (D).E-F. Mean ±SEM levels of IL-1β (E) and IL-6 (F) in extracts of the synovial membranes. *p < 0.05,p < 0.001, n=5 per group.