A. Joint inflammation scores of WT mice pretreated with vehicle or with recombinant human IL-38 (3–152) administered intraperitoneally 24, 12 and 2 hours prior to intraarticular instillation of streptococcal cell wall fragments.B. Levels of IL-6 in the synovial extract from mice shown in. Data are presented as mean ±SEM, *p < 0.05, **p < 0.01, ***p < 0.001, n=5 per group.