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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Cytokine. 2020 Oct 28;137:155334. doi: 10.1016/j.cyto.2020.155334

Figure 6. Effect of recombinant IL-38 on MSU/C16-induced peritonitis.

Figure 6.

Mice received human IL-38 (3–152) or vehicle 48, 24 and 2 hours prior to intraperitoneal instillation of MSU crystals (1 mg/mouse). Another group of mice received anakinra at 10 mg/kg one hour before MSU crystals.A. Abdominal wall temperature 4 hours after MSU crystals, immediately prior to anesthesia and sacrifice.B. Levels of peritoneal fluid KC.C. Plasma IL-6 and D. plasma KC 4 hours after MSU crystals. Data are presented as mean ±SEM, *p < 0.05, **p < 0.01 compared to vehicle, n=5 mice per group. Differences between vehicle and anakinra or vehicle and IL-38 are indicated above the bar.