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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Biol Psychiatry Cogn Neurosci Neuroimaging. 2020 Jun 30;5(12):1123–1133. doi: 10.1016/j.bpsc.2020.06.011

Table 5.

Paths for serial mediation analyses of the effect of impulsivity/hyperactivity symptoms on inhibition accuracy via the pallidal-thalamic-motor pathway

GPe/GPi
Thalamus
Motor
Accuracy
b SE P b SE P b SE P b SE P

Intercept b0 0.75 0.16 <.001 b0,1 0.26 0.18 <.001 b0,2 1.05 0.27 <.001 b0,3 83.4 2.8 <.001
Impulsivity a1 −0.35 0.13 .010 a2 −0.12 0.14 .376 a3 −0.25 0.21 .238 c1 −6.0 2.0 .004
GPe/GPi d1,2 0.67 0.10 .008 d1,3 0.47 0.18 .008 b1 −1.8 1.8 .319
Thalamus d2,3 0.37 0.14 .013 b2 −0.7 1.4 .618
M1 b3 2.7 1.0 .005
F, R2 6.87 0.06 .010 26.04 0.34 <.001 12.59 0.27 <.001 5.01 0.17 .001

Indirect Path Effect B. SE B. CI

Total Indirect Effect −0.61 0.91 −2.62 1.07
Impulsivity → GPe/GPi → Accuracy 0.62 0.77 −0.57 2.59
Impulsivity → GPe/GPi → Thalamus → Accuracy 0.17 0.27 −0.21 0.96
Impulsivity → GPe/GPi → M1 → Accuracy −0.45 0.28 −1.36 −0.11 x
Impulsivity → GPe/GPi → Thalamus → M1 → Accuracy −0.23 0.16 −0.76 −0.04 x
Impulsivity → Thalamus → Accuracy 0.09 0.20 −0.10 0.89
Impulsivity → Thalamus → M1 → Accuracy −0.12 0.16 −0.64 0.06
Impulsivity → M1 → Accuracy −0.67 0.69 −2.47 0.36

Note. x = P<.05; GPe/GPi=Globus Pallidus Pars Externa/Interna; M1=Primary Motor Cortex. t-statistic = b/SE. CI = confidence interval. B.SE = Bootstrapped Standard Error, B. CI = Bootstrapped confidence interval. The a paths are the associations between impulsivity and the mediator variables. The b paths are the associations between the mediator variable and inhibition accuracy. The c’ path is the direct effect of impulsivity on inhibition accuracy. The d path reflects the associations between the serial mediators.