Table 3.
Association of variants at 9p21.3 chromosomal region with anatomical categories of CAD.
| SNP (major/minor allele) | MAF in Controls N = 480 | Insignificant (n = 82) | Single vessel disease (n = 100) | Double vessel disease (n = 73) | Triple vessel disease (n = 66) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MAF | OR (95%CI) | p value | MAF | OR (95%CI) | p value | MAF | OR (95%CI) | p value | MAF | OR (95%CI) | p value | ||
| rs1333048(C/A) | 0.458 | 0.373 | 0.70 (0.51–0.97) | 0.032 | |||||||||
| rs17694493 (C/G) | 0.028 | 0.068 | 2.52 (1.28–4.98) | 0.006 | |||||||||
| *rs7865618 (A/G) | 0.409 | 0.493 | 1.425 (1.02–1.99) | 0.037 | 0.500 | 1.44 (1.05–1.98) | 0.022 | 0.516 | 1.53 (1.06–2.22) | 0.023 | |||
| rs1333040 (T/C) | 0.316 | 0.406 | 1.48 (1.02–2.13) | 0.036 | |||||||||
| rs10116277 (T/G) | 0.338 | 0.431 | 1.48 (1.02–2.15) | 0.037 | |||||||||
*Significantly associated in the sample of pooled CAD cases. Bold indicates the details of significant risk confering SNPs.