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. 2020 Dec 9;10:21584. doi: 10.1038/s41598-020-78128-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Weekly locomotor activity in proton irradiated and control rats. (a) Week-1 habituation curve. (b) Week-1 overall effects. (c) Week-2 habituation curve. (d) Week-2 overall effects. (e) Week-3 habituation curve. (f) Week-3 overall effects. (g) Week-4 habituation curve. (h) Week-4 overall effects. (i) Week-5 habituation curve. (j) Week-5 overall effects. For week 3 and 5 there were interactions. # week-3 (e) 11 Gy rats had reduced locomotion at 5-min, 14 Gy at 5 and 20 min, and 17 Gy at 5–25 and 40 min compared with controls. # week-5 (i) 11 Gy rats had reduced locomotion at 55 and 60 min and 17 Gy at 5–10 min compared with controls. *p < 0.05, **p < 0.01, ***p < 0.001 compared with controls. N = 10/group for all time points except at Week-4 for the 17 Gy, n = 9.