Table 3.
Summary of effects of whole brain single fraction conventional proton treatment.
| Assessment | Function | Associated primary brain region(s) | Effect—compared with 0 Gy Controls | ||
|---|---|---|---|---|---|
| 11 Gy | 14 Gy | 17 Gy | |||
| Locomotor activity | Spontaneous locomotion and exploration | Basal ganglia28 |
↓ Wk 2 |
↓↓ Wk 1–3 |
↓↓↓ Wk 1–5 |
| Rotorod | Motor coordination | Cerebellum69 | ─ | ─ | ─ |
| Novel Object Recognition | Novelty preference | Dorsal hippocampus27 | ─ | ─ | ─ |
| Prepulse startle inhibition | Sensory motor gating | Auditory/somatosensory cortex/colliculus70 | ↓ | ↓ | ↓ |
| Acoustic and tactile startle | Sensory function | Caudal pontine reticular nucleus29 | ─ | ─ | ─ |
| Cincinnati Water Maze (CWM) learning | Egocentric navigation | Striatum25 | ↓↓↓ | ↓↓ | ↓ |
| Morris water maze (MWM) learning | Allocentric navigation | Hippocampal/entorhinal cortex26 | ↓ | ↓ | ↓↓ |