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. 2020 Nov 25;11:586242. doi: 10.3389/fendo.2020.586242

Figure 5.

Figure 5

mRNA and protein expression after stimulation of 10-8 mol/L E2. (A, B) After E2 stimulation of 10-8 mol/L for 72 and 96 h, the mRNA level of Mfn2 was decreased, while the mRNA level of procollagen 1A1/1A2/3A1, ERα, ERβ, GPR30, and cyclinD1 were increased. (C, D) When uterosacral ligament fibroblasts in POP patients were stimulated by E2 at concentration of 10-8 mol/L for 72 and 96 h, the protein level of Mfn2 significantly decreased, whereas the expression of procollagen1A1/1A2/3A1, ERα, ERβ, GPR30, and cyclinD1 were gradually increased. (*P < 0.05, **P < 0.01, ***P < 0.001).