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. 2020 Nov 26;8:564648. doi: 10.3389/fcell.2020.564648

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Copyright © 2020 Abu, Othman, Ab Razak, Bakarurraini, Nasir, Soh, Mazlan, Azman and Jamal.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Uptake of PKH26 dye by the EVs as evaluated by flow cytometry analysis. (B) Normalized fold change of the apoptotic rate in the CD8T cells upon co-incubation with different groups of EVs; HighBMI-Non-CRC, LowBMI-non-CRC, HighBMI-CRC, and LowBMI-non-CRC. (C) Representative CFSE analysis in the CD8T cells co-cultured with CRC-EVs as evaluated by flow cytometry, HighBMI-CRC (n = 4), LowBMI-CRC (n = 4). PI, proliferation index. * indicates statistical significance at p < 0.05.