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. 2020 Dec 9;11:6318. doi: 10.1038/s41467-020-20136-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Enhancers were ranked by their H3K27ac CHIP-seq signals. The inflection point on the plotted curve was then selected as the cutoff to separate SEs from typical enhancers. SEs are indicated in red box. Typical enhancers are indicated in blue box. SEs were linked to their direct target genes by H3K27ac HiChIP. Genes important in B cell biology and oncogenesis are indicated by arrows. b SE-linked genes common in four PEL cell lines were analyzed using STRING (https://string-db.org/) with default settings. Gene interaction network formed around MYC is shown.