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. 2020 Nov 26;7:582890. doi: 10.3389/fcvm.2020.582890

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Copyright © 2020 Wang, Xie, Jiang, Wu, Xue, Dong, Fan, Dai, Chen, Li, Chen, Ye, Fang, Choy, Zhao, Dong and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hispidulin maintained mitochondrial ATP production and structural normality in mice. (A) Transmission electron microscopy was used for ultrastructural detection of mouse heart sections in each group. Scale bar reflects 0.5 μm (5800×) and 2 μm (26500×). (B,C) Quantification of individual mitochondrial areas and aspect ratios. Five images of each heart were evaluated (n = 3). (D) ATP concentrations in heart tissues were measured by a bioluminescence assay immediately after the hearts were harvested (n = 3). Data are expressed as the mean ± SE. Significance of the difference between DMSO+Sham and DMSO+AB: ^*p < 0.05; significance of the difference between DMSO+AB and Hispidulin+AB: ^#p < 0.05 (n represents the number of independent experiments).