TABLE 6.

Predicted side effects of the low molecular weight OHAs using PASS software.

Oligomer	Predicted side effects
O3HB 1U	Toxic by respiration (0.968), metabolic acidosis (0.927), eye irritation (0.907).
O3HB 2U–12U	Toxic by respiration (0.971), eye irritation (0.957).
O4HB 1U	Toxic by respiration (0.968), acidosis metabolic (0.948), euphoria (0.948), skin irritation (0.940)
O4HB 2U–12U	Toxic by respiration (0.979), euphoria (0.951), acidosis, metabolic (0.949), weakness (0.937), muscle weakness (0.935), eye irritation (0.929), conjunctivitis (0.915), dyspnea (0.905).
O3HV 1U	Toxic by respiration (0.944).
O3HV 2U–12U	Eye irritation (0.964), skin irritation (0.919), toxic by respiration (0.912), conjunctivitis (0.906).
O4HV 1u	Toxic by respiration (0.981), Acidosis metabolic (0.933), eye irritation (0.921), skin irritation (0.906).
O4HV 2U–12U	Toxic by respiration (0.982), eye irritation (0.963), skin irritation (0.918).
O3HVB	Eye irritation (0.975), skin irritation (0.940), toxic by respiration (0.926), conjunctivitis (0.912).
O3HBV, O3HVBV, O3HBVB, O3HVBVB, O3HBVBV	Eye irritation (0.978), skin irritation (0.964), toxic by respiration (0.944).
O4HBV, O4HVB, O4HBVB, O4HBVV, 04HVBV, O4HVBB	Eye irritation (0.982), toxic by respiration (0.980), skin irritation (0.973), conjunctivitis (0.925), dyspnea (0.919), acidosis metabolic (0.914).

The numbers in parentheses represent the probabilities that the mentioned side effects will occur. The predicted probabilities take values between 0 and 1. The values closer to 1 illustrate a high probability that these oligomers produce the mentioned side effects. Abbreviations are used as explained in Figure 2.