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. 2020 Nov 26;11:591559. doi: 10.3389/fendo.2020.591559

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Copyright © 2020 Poon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prenatal high-fat diet ingestion can increase circulating levels of CXCL12 in pregnant rats and also induces in offspring several changes in both behavior and in orexigenic peptide neurons in the arcuate nucleus (ARC), perifornical lateral hypothalamus (PFLH), and in the paraventricular nucleus of the hypothalamus (PVN). Prenatal HFD and prenatal CXCL12 overlap in their effects in offspring on increasing ENK levels in the PVN, and in increasing high-fat diet intake and anxiety-like behaviors.