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. 2020 Nov 26;8:588050. doi: 10.3389/fcell.2020.588050

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Copyright © 2020 Wang, Liu, Liu, Li, Wan, Yang, Su, Cheng, Liu, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cocultured ESCs promoted the G₁/S phase transition in replicative senescent RPE cells. (A) Proportion of cell cycle distribution in the PR, PRH, and PRHE groups, as assessed by flow cytometry (n = 3 biological repeats). (B) Proportion of cell cycle distribution in the RR and RRE groups, as assessed by flow cytometry (n = 3 biological repeats). Data are presented as the mean ± SD. ^∗∗P < 0.01; ^∗∗∗P < 0.001; ^****P < 0.0001.