Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 26;8:559486. doi: 10.3389/fcell.2020.559486

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Li, Li, Li, Zhou, Sikong, Gu, Jin, Li, Li and Zuo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Evidence that S100A10 functions as an oncogene in GC. (A) The mRNA expression of S100A10 in different human cancers and corresponding normal tissues from the Oncomine database. The number in the colored cell is the number of datasets meeting the thresholds. Cell color is determined by the gene rank. The color intensity (red or blue) is directly proportional to the significance level of upregulation or downregulation, respectively. (B,C) S100A10 expression in cancers. Expression level of S100A10 across 33 TCGA tumors compared to TCGA normal and GTEx data using the GEPIA (Gene Expression Profiling Interactive Analysis) webserver. An obvious upregulation of this gene was evident in 12 cancers. For each TCGA tumor (red), its matched normal and GTEx data (green) are given. The abbreviations denote T: tumor; N: normal; n: number. Y-axis: transcript per million [log2 (TPM + 1)]. X-axis: number of tumor and normal samples. ACC: adrenocortical carcinoma; BLCA: bladder urothelial carcinoma; BRCA: breast invasive carcinoma; CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL: cholangiocarcinoma; COAD: colon adenocarcinoma; DLBC: lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: esophageal carcinoma; GBM: glioblastoma multiforme; HNSC: head and neck squamous cell carcinoma; KICH: kidney chromophobe; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LAML: acute myeloid leukemia; LGG: brain lower grade glioma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; MESO: mesothelioma; OV: ovarian serous cystadenocarcinoma; PAAD: pancreatic adenocarcinoma; PCPG: pheochromocytoma and paraganglioma; PRAD: prostate adenocarcinoma; READ: rectum adenocarcinoma; SARC: sarcoma; SKCM: skin cutaneous melanoma; STAD: stomach adenocarcinoma; TGCT: testicular germ cell tumors; THCA: thyroid carcinoma; THYM: thymoma; UCEC: uterine corpus endometrial carcinoma; UCS: uterine carcinosarcoma; and UVM: uveal melanoma. (D) The expression level of S100A10 in GC and normal tissues using data from the TCGA database. (E) The expression of S100A10 in GC based on individual stages using the UALCAN database. (F) The expression of S100A10 in different GC subtypes compared to normal individuals derived from the Oncomine database. (G) S100A10 expression levels were associated with poor survival, as analyzed by the online program Kaplan-Meier Plotter. *P < 0.05, **P < 0.01, ***P < 0.001.