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. 2020 Nov 26;8:587693. doi: 10.3389/fcell.2020.587693

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Copyright © 2020 Ding, Zheng, Wang, Li, Xiang, Dou, Qiao, Tian, Ding and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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M1 macrophage was activated in the RIR-injured mice model. The mice were grouped and subjected to RIR operation. The serum and kidneys were separated on days 1 and 3 after the operation. (A) Serum SCr and BUN levels in the RIR-injured mice. (B) Representative periodic acid–Schiff (PAS) staining images of kidneys form RIR-injured or sham mice. Bar = 50 μm. (C) Representative IHC images of CD86 in the kidneys from RIR-injured mice were performed. Bar = 50 μm. (D,E) The mRNA expression level of inflammatory factors, including MCP-1, TNF-α, IL-1β, CD86, and iNOS in the RIR-injured kidney was assessed by qRT-PCR. (F) Expression of CD86 in macrophages was assessed by flow cytometry. Data presented as means ± SD for groups of three mice. *p < 0.05, **p < 0.01, ***p < 0.001 vs. the sham group. ^#p < 0.05, ^##p < 0.01 vs. the day 1 group.