TABLE 3.

Gene Ontology biological classification statistics of up-regulated genes in raptor silenced PHT cells.

Number of genes	High level Gene Ontology category	Genes
39	Response to stress	USP28 DEPDC5 BDKRB1 REC8 MASP1 OASL FIGN APOBEC3C UBE2V1 EPB41L4B MCM8 MDM2 IL6 TRIM26 PNPT1 ALAS2 ATF3 RFWD3 SPN CR1 ADCYAP1R1 PSEN1 CADM4 EZH2 GLP1R COL4A3BP MORC1 NFKBIZ ADM ISG20 NUB1 KIR3DL1 ROCK2 LGALS3BP SH2B1 LCK PRTN3 LILRB3 HLA-DQA2
32	Regulation of response to stimulus	CC2D1A MIB2 DEPDC5 MASP1 FIGN LCK SPRY4 IL6 EZH2 GRM4 MDM2 PNPT1 LGR5 ADM NETO1 NF2 CR1 ADCYAP1R1 PSEN1 CADM4 ARHGEF17 NFKBIZ RASA1 ATF3 SH2B1 RASAL3 RFWD3 UBE2V1 ROCK2 ICOS KIR3DL1 HLA-DQA2
32	Regulation of biological quality	MDGA1 USP28 PSEN1 SCN1B GLP1R CPLX2 SCN3B KLK1 MDM2 IL6 RASA1 ADM ADCYAP1R1 BDKRB1 EZH2 COL4A3BP LNPEP SPTBN5 CIZ1 ALAS2 NETO1 NF2 RASL10B LCK CYP4A11 FA2H MCM8 ROCK2 ZNF16 GRM4 SH2B1 PRTN3
30	Cellular localization	COL4A3BP C16ORF70 RABL2A CPLX2 LCA5L TSNARE1 PACS2 TBC1D3C EXOC3L2 GGA1 PSRC1 MDM2 ADCYAP1R1 PSEN1 PLA2G3 BDKRB1 EZH2 CIZ1 NETO1 NF2 ROCK2 PAF1 MCM8 SCN3B LCK HAO2 GRM4 SPTBN5 RPL32 TCTN2
30	Regulation of molecular function	SCN1B OASL LGR5 SCN3B SPRY4 TBC1D3C PSEN1 EZH2 GRM4 IL6 TRIM26 NETO1 ZNF16 LCK CR1 ADCYAP1R1 DEPDC5 RASAL3 PPP1R12C PSRC1 MDM2 RASA1 ADM DCP1B NF2 SPINK9 ROCK2 PRTN3 UBE2V1 GLP1R
29	Immune system process	MASP1 OASL LCK APOBEC3C IL6 PAF1 HOXA7 TRIM26 PRTN3 SPN CR1 LILRB3 PSEN1 PLA2G3 BDKRB1 NFKBIZ CPLX2 ALAS2 ICOS ISG20 HLA-DQA2 NUB1 RASAL3 KIR3DL1 ZNF16 COL4A3BP LNPEP SLC7A10 UBE2V1