TABLE 4.

Gene Ontology biological classification statistics of down-regulated genes in raptor silenced PHT cells.

Number of genes	High level Gene Ontology category	Genes
76	Catabolic process	PSMB1 SAMD4A ACAT1 ECHDC1 RBX1 ZC3H14 PSMA2 AKR1A1 MMP19 GALM QDPR HK3 SMPD1 ATG7 UBA52 APOC2 DECR1 NUDT1 SKP1 SPP1 RPL23 CYP19A1 AZIN1 PRDX3 HPRT1 ACOT4 BCAP31 APOBEC3G VPS41 SIRT2 SNX5 TREM2 TSPO PLA2G15 BLVRA APAF1 PLBD1 DDA1 NPL HINT2 ESD TMEM208 LSM3 VDAC1 PGAM4 PDXP YBX1 FEZ2 NRBP2 ATP6V0E1 RPS20 TYMP DYNLL1 RPL18A LSM5 RPS12 PCCB RPL22 RPL21 RPS10 CHMP2A RPS15A GLUL RPS6 SEC13 RPL26 PTTG1 FABP5 ALDH1A1 FABP4 RPS9 RPS27 RPL12 RPL23A RPS28 CEBPA
74	Cellular component biogenesis	VPS41 RPL26L1 GAR1 NDUFB3 NCKAP1L RPS10 ORMDL1 DYNC2LI1 SRP19 C10ORF90 VBP1 RPL26 MAPRE2 LSM3 RSL1D1 RPS27 NDUFAF3 ATG7 RPL12 RPL23A RPS28 PPM1A DECR1 UGDH RTN4 RAB32 KHDRBS1 PRMT1 TRA2B APIP GBP5 SEC13 H3F3A HPRT1 RXRA PDXP SIRT2 CNGB1 ACAT1 KCNC4 APAF1 GTF3A GLUL BIN1 POLR1E RPS6 GCHFR G3BP2 PTPRO PDLIM5 GPBAR1 TSPYL1 EIF3CL NDUFB2 RAP2A NDUFA1 CHMP2A NDUFB9 FCER1G FEZ2 HAUS7 FGD2 TCP1 HSPB11 DYNLL1 RBX1 TRIP11 SKP1 CENPL TUBA1A RPS9 NDUFV2 UBA52 APOC2
60	Regulation of signaling	ATP2C1 LGALS1 PPM1A LGALS9 LRP5L DUSP2 CCKAR TXN TREM2 EZH2 AAK1 SPP1 RAP2A CYP19A1 TBC1D16 S100A4 TYMP SNX5 CA2 RTN4 RPL22 KCNC4 NENF APAF1 KHDRBS1 CHSY1 SERINC3 HAVCR2 GLUL CTDSPL2 SOD1 FGD2 APIP PTPRO SEC13 FABP5 MAPRE2 IL16 ATP2A2 UFSP2 PFDN5 RPL23 DSTYK ARL6IP5 RPL26 SMPD1 BCAP31 LILRA5 PRMT1 PSMB1 GDI2 CNGB1 RBX1 PSMA2 ATP1B1 IFNAR2 BRD7 FPR1 ARHGAP30 UBA52