Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 26;10:564614. doi: 10.3389/fonc.2020.564614

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Zhang, Li, Yang, Cao and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

FMNL1 is overexpressed in ccRCC. (A) Total RNA was extracted from 20 paired ccRCC and corresponding nontumorous tissues (NT) to examine the expression of FMNL1 mRNA by qRT-PCR. (B) The mRNA level in ccRCC patients from TCGA dataset was shown (C). The upregulation of FMNL1 mRNA expression in ccRCC tissues was validated in previous studies of Gumz and Yusenko. (D) The protein expression of FMNL1 was examined by western blot in 20 ccRCC specimens. Representative images were shown. (E) A cohort containing 306 ccRCC patents was recruited to construct TMA. IHC was performed to indicate the FMNL1 expression. FMNL1 expression in tumor and nontumorous tissues, and in ccRCC tissues with or without tumor metastasis was indicated by box and whiskers. (F) Patients were divided into FMNL1^high and FMNL1^low groups, according to the IHC score of FMNL1 in ccRCC tissues. Kaplan-Meier survival analyses were performed to reveal the prognostic value of FMNL1 in overall and disease-free survivals of ccRCC patients. (G) The prognostic value of FMNL1 in ccRCC was confirmed in TCGA cohort.