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. 2020 Nov 26;11:595733. doi: 10.3389/fgene.2020.595733

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Copyright © 2020 Geng, Zheng, Zhao, Huang, Qiang, Zhang, Guo and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ERα regulates RNF183 expression and increases its stability. The expression of endogenous RNF183 mRNA (A) and protein levels (B) in Ishikawa cells after transfecting with siERα or siNC. (C) Downregulated RNF183 protein level reduced by siERα was recovered based on MG132 treatment. (D) Depletion ERα weakens RNF183 stability. RNF183 protein level examined at indicated time after transfected with siERα 48h followed 100μg/mL cycloheximide treatment. Experiments were repeated in triplicates. Mean ± S.D. (n = 3). *P<0.05.