TABLE 1.
Correlation analysis between RNF183 and relate genes and markers of immune cells in TIMER.
| Description | Gene markers |
UCEC |
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|
None |
Purity |
||||
| Cor | P | Cor | P | ||
| CD8 + T cell | CD8A | –0.052 | 2.22e–01 | –0.119 | 4.16e–02 |
| CD8B | –0.027 | 5.22e–01 | –0.031 | 6.02e–01 | |
| T cell (general) | CD3D | –0.046 | 2.82e–01 | 0 | 9.98e–01 |
| CD3E | –0.037 | 3.86e–01 | –0.027 | 6.49e–01 | |
| CD2 | –0.015 | 7.22e–01 | –0.018 | 7.64e–01 | |
| B cell | CD19 | –0.026 | 5.52 e–01 | –0.051 | 3.81e–01 |
| CD79A | –0.023 | 5.88e–01 | –0.121 | * | |
| Monocyte | CD86 | –0.094 | * | –0.087 | 1.36e–01 |
| CD115 | –0.025 | 5.57e–01 | –0.011 | 8.54e–01 | |
| TAM | CCL2 | –0.013 | 7.85e–01 | 0.048 | 4.09e–01 |
| CD68 | –0.07 | 1.01e–01 | –0.066 | 2.60e–01 | |
| M1 Macrophage | iNOS | –0.26 | 7.61e–01 | –0.256 | *** |
| IRF5 | –0.074 | 8.38e–02 | –0.107 | 6.65e–02 | |
| COX2 | –0.12 | ** | 0.085 | 1.46e–01 | |
| M2 Macrophage | CD163 | –0.183 | *** | –0.182 | ** |
| VSIG4 | –0.114 | ** | –0.122 | * | |
| MS4A4A | –0.131 | ** | –0.146 | * | |
| Neutrophils | CD66b | 0.07 | 1e–01 | 0.023 | 6.92e–01 |
| CD11b | 0.089 | * | 0.092 | 1.16e–01 | |
| CCR7 | 0.014 | 7.44e–01 | –0.047 | 4.18e–01 | |
| Natural killer cell | KIR2DL1 | 0.028 | 5.16e–01 | 0.005 | 9.34e–01 |
| KIR2DL3 | 0.028 | 5.17e–01 | –0.029 | 6.27e–01 | |
| KIR2DL4 | 0.039 | 3.67e–01 | –0.032 | 5.82e–01 | |
| KIR3DL1 | 0.045 | 2.94e–01 | 0.016 | 7.81e–01 | |
| KIR3DL2 | –0.74 | 8.43e–02 | –0.027 | 6.41e–01 | |
| KIR3DL3 | –0.004 | 9.23e–01 | –0.034 | 5.62e–01 | |
| KIR2DL4 | 0.039 | 3.67e–01 | –0.032 | 5.82e–01 | |
| Dendritic cell | HLA-DPB1 | 0.083 | 5.27e–02 | 0.055 | 3.44e–01 |
| HLA-DQB1 | 0.134 | ** | 0.099 | 9.00e–02 | |
| HLA-DRA | 0.144 | *** | 0.125 | * | |
| HLA-DPA1 | 0.051 | 2.33e–01 | 0.018 | 7.60e–01 | |
| BDCA-1 | 0.275 | *** | 0.249 | *** | |
| BDCA-4 | 0.219 | *** | 0.172 | ** | |
| CD11c | 0.094 | * | 0.098 | 9.52e–02 | |
| Th1 | T-bet | 0.025 | 5.53e–01 | –0.048 | 4.16e–01 |
| STAT4 | 0.067 | 1.18e–01 | –0.037 | 5.29e–01 | |
| STAT1 | –0.256 | *** | –0.252 | *** | |
| IFN-γ | –0.104 | * | –0.138 | ** | |
| TNF-α | 0.044 | 3.06e–01 | 0.004 | 9.50e–01 | |
| Th2 | GATA3 | –0.113 | ** | –0.217 | *** |
| STAT6 | 0.25 | *** | 0.197 | *** | |
| STAT5A | 0.014 | 7.47e–01 | –0.009 | 8.73e–01 | |
| IL13 | –0.021 | 6.18e–01 | 0.007 | 9.90e–01 | |
| IL21 | –0.007 | 8.69e–01 | –0.058 | 3.23e–01 | |
| Th17 | STAT3 | 0.202 | *** | –0.156 | 7.43e–03 |
| IL17A | 0.005 | 9.15e–01 | 0 | 9.96e–01 | |
| Treg | FOXP3 | 0.008 | 8.6e–01 | –0.083 | 1.57e–01 |
| CCR8 | 0.067 | 1.18e–01 | –0.001 | 9.93e–01 | |
| STAT5B | 0.035 | 4.17e–01 | –0.076 | 1.97e–01 | |
| TGFβ | –0.172 | *** | –0.251 | *** | |
| T cell exhaustion | PD-1 | –0.12 | ** | –0.144 | ** |
| CTLA4 | 0.038 | 3.72e–01 | –0.002 | 9.78e–01 | |
| LAG3 | –0.222 | *** | –0.296 | *** | |
| TIM-3 | –0.078 | 6.81e–02 | –0.097 | 9.62e–02 | |
| GZMB | –0.151 | *** | –0.172 | ** | |
TAM, tumor-associated macrophage; Th, T helper cell; Treg, regulatory T cell; Cor, P value of Spearman’s correlation; None, correlation without adjustment. Purity, correlation adjusted by purity. *P < 0.05, **P < 0.01, ***P < 0.001.