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. 2020 Nov 26;10:574525. doi: 10.3389/fonc.2020.574525

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Copyright © 2020 Li, Lim, Tao, Li, Xie, Yang, Zhang, Jiang, Zhang, Cao, Wang, Qian, Wu, Li, Fang, Liu, Fu, Ding, Zhu, Lv, Lu, Xiao, Hu and Pan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ARV-825 elicits cell cycle arrest and apoptosis in NB cells. (A) Cell cycle analysis showed ARV-825 induced an increased proportion of the G1 phase and concurrently decreased S and G2 proportion in NB cells. (B) Annexin V/PI staining showed an increased proportion of apoptotic cells in NB cells after treated with ARV-825 at indicated concentrations. (C) The proportion of apoptotic cells increased significantly in NB cells treated by ARV-825. ***p < 0.001.