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. 2020 Nov 26;11:593416. doi: 10.3389/fphar.2020.593416

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Copyright © 2020 Betari, Sahlholm, Morató, Godoy-Marín, Jauregui, Teigen, Ciruela and Haavik

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Selectivity of omeprazole to inhibit TPH1 over other aromatic amino acid hydroxylases. In vitro enzyme assays were used to evaluate the selectivity of omeprazole to inhibit TPH1 over the other aromatic amino acid hydroxylases; TPH2, TH, and PAH. TPH1, doubly truncated tryptophan hydroxylase 1 (ΔNH102-ΔCOOH402); TPH2, tryptophan hydroxylase two; PAH, phenylalanine hydroxylase, TH tyrosine hydroxylase. The data are expressed as means ± SEM; from three independent experiments, each performed in duplicate.