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. 2020 Dec 9;40(50):9725–9735. doi: 10.1523/JNEUROSCI.1809-20.2020

Figure 2.

Figure 2.

Chronic HFHS diet alters spontaneous but not evoked GABA neurotransmission in the ventral pallidum. A, The cumulative probability plot of sIPSC amplitude (amp.) is shifted to the left in HFHS mice, pointing to reduced sIPSC amplitude (Kolmogorov–Smirnov test). Inset, Median sIPSC amplitude was lower in HFHS mice (unpaired two-tailed t test). B, HFHS diet did not affect the interevent interval (IEI) of sIPSCs in the VP (Kolmogorov–Smirnov test). Inset, Comparison of medians (unpaired two-tailed t test). C, Representative sIPSC traces. D, E, HFHS diet did not affect short-term plasticity induced by five consecutive stimulations at 10 Hz (D) or 50 Hz (E; two-way ANCOVA). Insets, Representative traces synchronized with x-axis. Stimulation artifacts were truncated. F, G, The amplitude of evoked IPSCs after an HFS did not differ between chow and HFHS mice (mixed-effects ANOVA), or from baseline (one-sample two-tailed t test on minutes 13–19). Inset, Representative traces. H, Post-tetanic potentiation, measured at the first time point after the HFS, did not differ between groups (unpaired two-tailed t test). Data taken from 19–41 cells in 13–24 mice/group. Data are presented as the mean ± SEM. n.s., not significant.