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Reinstatement of forebrain E2 levels by exogenous E2 administration can rescue the suppressed reactive astrocyte genes in the ovx-female GFAP-ARO-KO hippocampus after GCI. qRT-PCR analysis for PAN-specific (A) and A2-specific (B) reactive astrocyte genes expression level in FLOX-GCI-placebo, KO-GCI-placebo, and KO-GCI-E2 hippocampus at R3d. Data are mean ± SEM; n = 3–5; *p < 0.05 versus FLOX-GCI +PL, &p < 0.05 versus KO – GCI + PL, one-way ANOVA followed by post hoc tests.
