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. 2020 Dec 9;10:21501. doi: 10.1038/s41598-020-78692-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Decreased intact FGF23 levels in Pten_Ocy^−/− mice. (a) and (b) An immunohistochemical analysis of FGF23 in the femur was performed on 16-week-old male mice. A representative image of three independent experiments is shown (a). The percentage of FGF23-positive osteocytes over total osteocytes was counted (N = 3) (b). (c) The bone extracts of the femur were prepared from 16-week-old male mice and intact FGF23 concentration was measured (N = 8). (d–f) Serum levels of intact FGF23 (male: N = 11, female: N = 7–8) (d), Pi (male: N = 10–11, female: N = 11–13) (e), and Ca (male: N = 10–11, female: N = 11–13) (f) were measured in 16-week-old mice. Statistical analysis was performed by Mann–Whitney U test. *p < 0.01; **p < 0.05, ns: not significantly different.