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. 2020 Dec 9;10:21492. doi: 10.1038/s41598-020-76338-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of the PMO-based let-7c SBO strategy to alleviate let-7c miRNA repression of utrophin gene. The left panel shows, let-7c miRNA mediated post-transcriptional repression of utrophin in control PMO treated mice. Whereas, the right panel shows let-7c PMO mediated blocking of miRNA binding to UTRN 3′UTR, resulting in higher utrophin expression and improvement in dystrophic pathophysiology.